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» ISCEON™ MO49Plus™ refrigerant in the United States
» ISCEON™ refrigerants solutions in Europe

ISCEON™ MO49Plus™ (R-437A) is an HFC retrofit refrigerant for R-12 in automotive air conditioning and stationary refrigeration systems, and for replacing HCFC-containing refrigerant blends (e.g., MP39, MP66, and R-409A) in stationary refrigeration systems. ISCEON™ MO49Plus™ is compatible with traditional and new lubricants; in most cases no change of lubricant during retrofit is required.

ISCEON™ MO49Plus™ is not recommended for use in centrifugal compressor systems or for chillers with flooded evaporators or low pressure receivers.

Note: ISCEON™ MO49Plus™ is not available for automotive air-conditioning in the U.S.

» ISCEON™ MO49Plus™ Case Histories


R-437A; A1 Safety Classification.

ISCEON™ MO49Plus™ has an ASHRAE safety classification of A1 and is non-flammable as formulated and under leakage scenarios as specified in ASHRAE Standard 34-2007. Refer to the Safety of Refrigerants bulletin and the Safety Data sheet for details.


ISCEON™ MO49Plus™ replaces R-12, HCFC-containing blends (e.g., MP39, MP66, and R-409A), and ISCEON™ MO49 (R-413A).


  • Automotive AC systems designed for R-12
  • Refrigeration systems designed for R-12, including:
    • Food service
    • Supermarket display cases
    • Food storage and processing
    • Domestic refrigerators/freezers


  • Provides cost-effective retrofits
    • Replaces R-12 and HCFC-containing blends, such as MP39, MP66,
      and R-409A
    • Replaces ISCEON™ MO49 (R-413A)   
  • Non-ozone-depleting HFC retrofit refrigerant 
    • Not subject to phaseout under the Montreal Protocol 
  • Compatible with traditional lubricants
    • In most cases, no change of lubricant type is needed
  • Enables continued use of existing equipment


  • Provides similar to slightly lower efficiency vs. R-12
  • Provides lower discharge temperature vs. R-12

Phaseout Schedule 
ISCEON™ MO49Plus™ is a non-ozone-depleting substance (ODS) and, therefore, is not subject to phaseout under the Montreal Protocol regulations. 

Lubricant Recommendation

In automotive air-conditioning and stationary refrigeration systems, ISCEON™ MO49Plus™ is compatible with traditional and new lubricants. In most cases, no change of lubricant type during retrofit is needed. Refer to the ISCEON™ MO49Plus™ Retrofit Guidelines (for Stationary Refrigeration or Automotive AC) for details.